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1
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Principles of toxicology
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1. Understand
the definitions related to the scope
and application of toxicology
2. Comprehend principles of dose response relationship and toxins kinetics
3. List the factors affecting dose response
4. Know types of toxic responses and List unusual toxic response and
their examples
5. Differentiate types of chemical interactions
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2
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Approach to management of patient with suspected acute poisoning
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1. Apply supportive medicine
2. Recognize patients with
suspected poisoning
3. Apply method for patient stabilization
4. Evaluate patients with suspected poisoning
5. Apply procedures to decontaminate the poison
6. Apply procedures to enhance illumination of the poison
6. Knows when and how to apply antidotes
7. Apply procedure to continuous support for the patient
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3
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Alcohol poisoning (ethanol, Methanol, Ethylene glycols)
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1. Know briefly the sources, absorption, metabolism and elimination
of alcohols.
2. Know the measurement of ethanol consumption in units.
3. Know the toxic effects of these alcohols and their mechanism of
action.
4. Know the local and some foreign laws concerning drinking &
driving.
5. Interpret clinical findings in relation to alcohols levels.
6. Understand alcohols related causes of death.
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4
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Toxic gases and volatiles
(Carbon monoxide, cyanide and sulfides)
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1.Konw the physical characteristics of these gases
2. Recognize the sources and circumstances of poisoning
3. Explain the mechanism of toxicity
4. Explain their toxicokinetics
5. Recognize acute poisoning and list their clinical manifestation
6.Conduct the proper investigations
7. Manage poisoned patients
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5
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Substance of Abuse
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1. Know the terms related to substance of abuse.
2. Know the local Laws and regulations related to psychoactive
substances and drugs of abuse.
3. List examples of abusable substances to include common CNS
depressants, Stimulants and Hallucinogen agents
4. List examples for each category
5. Recognize method of abuse, manifestation of abuse and toxicity of
them, mechanism of action and investigations
6. Outline management approach for acute poisoning and physical
dependence
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6
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Pesticides (Organophosphates, carbamates)
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1.Type on common pesticides
2.Mechanism of toxicity of insecticides
2.Toxicokinetics
3.Recognize acute poisoning and their clinical manifestation
4.Management of acute poisoning
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7
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Common drug poisoning (acetaminophen and designer drugs)
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1.Sources of exposure
2. Mechanism of toxicity
3.Absorption, metabolism and excretion
4.Acute poisoning and clinical manifestation of poisoning
5. Recognize manifestations of designer drugs abuse
6.Treatment of poisoning
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Doping in sport
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1.Prohibited list
2.Prohibited method and types of
doping
3.Role of physician
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9
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Miscellaneous poisons
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