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My research interests focus on protein translocation across the endoplasmic reticulum membrane as it relates to the unfolded protein response (UPR) and apoptosis. We have previously shown that chymeric proteins resulting from the fusion of a functional signal sequence to cytoplasmic proteins results in degradation of the protein as a result of being targeted to the membrane and recognized as foreign and misfolded protein. I am interested in intracellular signaling pathways leading to nuclear communication with the ER as the later is subjected to mild or overwhelming stress. Less susceptibility to cell death upon activation of the UPR may contribute to tumor progression and drug resistance of solid tumors. It is hoped that a better understanding of the response to ER stress might enable the development of new therapies which exploit the UPR, leading to cell death and an enhanced therapeutic effect against solid tumors