Published Research

Research Title

Authors

Journal

Volume & Page Numbers

Publisher

Year

Structure‐Based Approaches for the Prediction of Alzheimer's Disease Inhibitors: Comparative Interactions Analysis, Pharmacophore Modeling and Molecular Dynamics Simulations

Enfale Zerroug, Salah Belaidi, Samir Chtita, Ghada Tuffaha, Faizan AbulQais, Mateusz Kciuk, Amit Dubey, Mutasem O Taha

ChemistrySelect

9, e202303307

Wiley-VCH

2024

Preparation of novel shell-ionotropically crosslinked micelles based on hexadecylamine and tripolyphosphate for cancer drug delivery

Enas Alkhafaji, Isra Dmour, Mohamed K Al-Essa, Walhan Alshaer, Ahmad Aljaberi, Enam A Khalil, Mutasem O Taha

Pharmaceutical Development and Technology

29, 4, 322-338

Taylor & Francis

2024

Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic anticancer leads

Al-Mahadeen, Mohammed M.; Jaber, Areej M.; Zahra, Jalal A.; El-Abadelah, Mustafa M.; Alshaer, Walhan; Taha, Mutasem O.

Medicinal Chemistry Research

Volume 33, Issue 6, Pages 918 - 929

Springer Nature

2024

Discovery of novel chemotype inhibitors targeting Anaplastic Lymphoma Kinase receptor through ligand-based pharmacophore modelling.

El-Jundi, I., Daoud, S., & Taha, M. O.

SAR and QSAR in Environmental Research

35(9), 795–815.

SAR and QSAR in Environmental Research

2024

Ligand-based pharmacophore modeling and machine learning for the discovery of potent aurora A kinase inhibitory leads of novel chemotypes

Rajaa Banat, Safa Daoud, Mutasem Omar Taha

Molecular Diversity

28, 4241–4257

Springer Nature

2024

Dipeptidyl Peptidase-IV Blockers Potently Inhibit Monoglyceride Lipase: Investigation By Docking Studies And In Vitro Bioassay

Dania Alkabbani, Lina A Dahabiyeh, Mutasem O Taha

Medicinal Chemistry Research

32, 165–175

Springer

2023

A Click Synthesis, Molecular Docking and Biological Evaluation of 1,2,3-triazoles-benzoxazepine hybrid as potential anticancer agents

Muhammad Ashram, Almeqdad Y. Habashneh, Sanaa Bardaweel & Mutasem O. Taha

Medicinal Chemistry Research

32, 271–287

Springer

2023

Discovery of new STAT3 inhibitors as anticancer agents using ligand-receptor contact fingerprints and docking-augmented machine learning

Nour Jamal Jaradat, Walhan Alshaer, Mamon Hatmal and Mutasem Omar Taha

RSC Advances

13, 4623-4640

Royal Society of Chemistry

2023

Asenapine as a Potential Lead Inhibitor against Central Ca2+/Calmodulin-Dependent Protein Kinase II: Investigation by Docking Simulation and Experimental Validation

Safa Daoud Reem Abutayeh Shada J. Alabed Mutasem O. Taha

The Open Medicinal Chemistry Journal

17, e187410452301260

Bentham

2023

Molecular docking, molecular dynamics simulations and in vitro screening reveal cefixime and ceftriaxone as GSK3β covalent inhibitors†

Nassar, Husam Sippl, Wolfgang Dahab, Rana Abu Taha, Mutasem

RSC Advances

13, 11278-11290

Royal Society of Chemistry

2023

Development of phosphoinositide 3-kinase delta (PI3Kδ) inhibitors as potential anticancer agents through the generation of ligand-based pharmacophores and biological screening

Mahmoud A. Al-Sha’er, Mutasem Taha Mahmoud A. Alelaimat

Medicinal Chemistry Research

32, 1109–1121

Springer

2023

Tableting-induced mechanochemical matrix crosslinking: Towards non-disintegrating chitosan-based sustained delivery tablets

Isra Dmour Mutasem Omar Taha

Journal of Drug Delivery Science and Technology

86,104696

Elsiever

2023

Augmenting bioactivity by docking-generated multiple ligand poses to enhance machine learning and pharmacophore modelling: discovery of new TTK inhibitors as case study

Amenah M. AL-Imam, Safa Daoud, Ma'mon M. Hatmal, Mutasem Omar Taha

Molecular Informatics

42, 6, 2300022

Wiley

2023

Computational workflow for discovering small molecular binders for shallow binding sites by integrating molecular dynamics simulation, pharmacophore modeling, and machine learning: STAT3 as case study

Nour Jamal Jaradat, Mamon Hatmal, Dana Alqudah Mutasem Omar Taha

Journal of Computer-Aided Molecular Design

Springer

2023

Synthesis, anticancer evaluation and docking studies of novel adamantanyl-1,3,4-oxadiazol hybrid compounds as Aurora-A kinase inhibitors

Jaber, Areej M. Al-Mahadeen, Mohammed M. Al-Qawasmeh, Raed A. Taha, Mutasem O.

Medicinal Chemistry Research

Volume 32, Issue 11, Pages 2394 - 2404

Springer

2023

Exploiting activity cliffs for building pharmacophore models and comparison with other pharmacophore generation methods: sphingosine kinase 1 as case study

Lubabah A Mousa Ma'mon M Hatmal Mutasem Omar Taha

Journal of Computer-Aided Molecular Design

Springer

2022

Ligand-Based Modeling of CXC Chemokine Receptor 4 and Identification of Inhibitors of Novel Chemotypes as Potential Leads towards New Anti-COVID-19 Treatments

Safa Dauod Mutasem Taha

Medicinal Chemistry

Bentham

2022

Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/ receptor contact fingerprints and machine learning

Mai Fayiz Al-Tawil; Safa DaoudSafa Daoud; Ma'mon M Hatmal; Mutasem Omar Taha

RSC Advances

12, 10686-10700

Royal Society of Chemistry

2022

Discovery of new PKN2 inhibitory chemotypes via QSAR-guided selection of docking-based pharmacophores

Mahmoud A Al-Sha’er, Haneen A Basheer, Mutasem O Taha

Molecular Diversity

Springer Nature

2022

Vitamin B12 binding to mutated human transcobalamin, in-silico study of TCN2 alanine scanning and ClinVar missense mutations/SNPs

Omar Abuyaman, Ma’mon M Hatmal, Nawal Hijjawi, Ahmad A Deeb, Mohammad Abuothman, Mutasem Taha

Journal of Biomolecular Structure and Dynamics

Taylor & Francis

2022

Reported Adverse Effects and Attitudes among Arab Populations Following COVID-19 Vaccination: A Large-Scale Multinational Study Implementing Machine Learning Tools in Predicting Post-Vaccination Adverse Effects Based on Predisposing Factors

Ma’mon M Hatmal, Mohammad AI Al-Hatamleh, Amin N Olaimat, Rohimah Mohamud, Mirna Fawaz, Elham T Kateeb, Omar K Alkhairy, Reema Tayyem, Mohamed Lounis, Marwan Al-Raeei, Rasheed K Dana, Hamzeh J Al-Ameer, Mutasem O Taha, Khalid M Bindayna

Vaccines

10, 366

MDPI

2022

Pharmacophore Modeling of Targets Infested with Activity Cliffs via Molecular Dynamics Simulation Coupled with QSAR and Comparison with other Pharmacophore Generation Methods: KDR as Case Study

Alaa Abudayah, Safa Daoud, Mahmoud A. Al-Sha'er, Mutasem Omar Taha

Molecular Informatics

9, 400

Wiley

2022

Discovery of new potent lysine specific histone demythelase-1 inhibitors (LSD-1) using structure based and ligand based molecular modelling and machine learning†

Shada J. Alabed, Malek Zihlif, Mutasem Taha*

RSC Advances

12, 35873-35895

Royal Society of Chemistry

2022

Novel Ellipsoid Chitosan-Phthalate Lecithin Nanoparticles for siRNA Delivery

Ramzi Mukred Saeed, Mohammed Abdullah, Mamoun Ahram, Mutasem Omar Taha

Frontiers in Bioengineering and Biotechnology

9, 589

Frontiers

2021

Structure-based discovery of new polo-like kinase 1 (PLK1) inhibitors as potential anticancer agents via docking-based comparative intermolecular contacts analysis (dbCICA)

Saja Al-Assaf Areej Abuhammad Majd S. Hijjawi Mutasem Omar Taha

Medicinal Chemistry Research

Springer

2021

Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease

Izzeddin Alsalahat Zubida Al-majdoub Mutasem Omar Taha Jill Barber Harmesh Aojula Nigel Hodson Sally Freeman

Biochemistry and Biophysics Reports

Elsevier

2021

Docking-Generated Multiple Ligand Poses for Bootstrapping Bioactivity Classifying Machine Learning: Repurposing Covalent Inhibitors for COVID-19-Related TMPRSS2 as Case Study

Ma'mon M Hatmal; Omar Abuyaman; Mutasem Omar Taha

Computational and Structural Biotechnology Journal

19, 4790-4824

Elsivier

2021

Pharmacophore modeling of JAK1: A target infested with activity-cliffs

Safa Dauod Mutasem Taha

Jornal of Molecular Graphics and Modelling

99, 1, 1-10

Elsevier

2020

Elaboration of Novel TTK1 Inhibitory Leads via QSAR-Guided Selection of Crystallographic Pharmacophores Followed By In vitro Assay.

Mahmoud Al-Shaer Mutasem Taha

Current Computer-aided Drug Design

15, 1, 1-10

Bentham

2020

Structure-Based Discovery and Bioactivity Evaluation of Novel Aurora-A Kinase Inhibitors as Anticancer Agents via Docking-Based Comparative Intermolecular Contacts Analysis (dbCICA)

Majd S. Hijjawi Reem Abutayeh Mutasem Omar Taha

Molecules

25, 6003

MDPI

2020

Design and Synthesis of New JAK1 Inhibitors based on SulfonamideTriazine Conjugates

Safa Dauod Mutasem Taha

Current Computer-Aided Drug Design

12, 1

Bentham

2020

Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents

Iman Mansi, Mahmoud A Al-Sha'er, Nizar Mhaidat, Mutasem Taha

Anti-Cancer Agents in Medicinal Chemistry

20, 476-485

Bentham

2020

Discovery of novel Flt3 inhibitory chemotypes through extensive ligand-based and new structure-based pharmacophore modeling methods

Reem Fawaz Abutayeh Mutasem O. Taha

Journal of Molecular Graphics and Modelling

88, 128-151

Elsevier

2019

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

Mahmoud A. Al-Sha'er Rua’a A. Al-Aqtash Mutasem O. Taha

Medicinal Chemistry

15, 1-14

Bentham

2019

Design and Synthesis of New Sulfonamides–Based Flt3 Inhibitors

Reem Fawaz Abutayeh, Jehad Almaliti Mutasem O. Taha

Medicinal Chemistry

1-10

Bentham

2019

QSAR-guided pharmacophore modeling and subsequent virtual screening identify novel TYK2 inhibitor

Elham Y. Al-Barghouthy Areej Abuhammad Mutasem O. Taha

Medicinal Chemistry Research

Springer

2019

Combining Stochastic Deformation/Relaxation and Intermolecular Contacts Analysis for Extracting Pharmacophores from Ligand-Receptor Complexes.

Ma’mon M. Hatmal Mutasem O. Taha

Journal of Chemical Information and Modeling

58 (4), pp 879–893

American Chemical Society

2018

Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3inhibitor

Mahmoud A. Al-Sha’er Mutasem O. Taha

Journal of Molecular Graphics and Modelling

82, 1-13

Elsevier

2018

Discovery of new Gyrase b inhibitors via structure based modeling

Afaf H. Al-Nadaf, Sajeda A. Salah, Mutasem O. Taha

Computational Biology and Chemistry

74, 263–272

Elsevier

2018

Synthesis and Structure-Activity Relationship; Exploration of Some Potent Anti-Cancer Phenyl Amidrazone Derivatives

Almeqdad Y. Habashneh, Mustafa M. El-Abadelah, Sanaa K Bardaweel, Mutasem O. Taha

Medicinal Chemistry

14, 1-10

Bentham Science Publishers

2018

Simulated annealing molecular dynamics and Lingand–receptor contacts analysis for pharmacophore modeling

Ma’mon M Hatmal Mutasem O Taha

Future Medicinal chemistry

9 (11), 1141-1159

Future Science Ltd London, UK

2017

Novel nanoparticles based on chitosan-dicarboxylate conjugates via tandem ionotropic/covalent crosslinking with tripolyphosphate and subsequent evaluation as drug delivery vehicles

Isra Dmour Mutasem O. Taha

International Journal of Pharmaceutics

529; 15–31

Elsevier

2017

Docking-based comparative intermolecular contacts analysis and in silico screening reveal new potent acetylcholinesterase inhibitors

Maha Habash ● Sawsan Abuhamdah ● Khaled Younis3● Mutasem O. Taha

Medicinal Chemistry Research

Volume 26, Issue 11, pp 2768–2784

Springer

2017

Synthesis and characterization of chitosan-lactate–phthalate and evaluation of the corresponding zinc- and aluminumcrosslinked beads as potential controlled release matrices

Ramia Z. Al Bakain Samer R. Abulateefeh Mutasem O. Taha

European Polymer Journal

73, 402–412

Elsevier

2016

Ligand-based modeling of diverse aryalkylamines yields new potent P-glycoprotein inhibitors

Dana A. AlQudah Malek A. Zihlif Mutasem O. Taha

European Journal of Medicinal Chemistry

110, 204-223

Elsevier

2016

QSAR studies in the discovery of novel type-II diabetic therapies

Areej Abuhammad Mutasem O. Taha

Expert Opinion on Drug Discovery

11, 197-214

Taylor & Francis

2016

Novel anticancer compound [trifluoromethyl-substituted pyrazole N-nucleoside] inhibits FLT3 activity to induce differentiation in acute myeloid leukemia cells

Ayman M. Saleh, Mutasem O. Taha, Mohammad A. Aziz, Mahmoud A. Al-Qudah, Reem Abu Tayeh, Syed A. Rizvi

Cancer Letters

Volume 375, Issue 2, Pages 199–208

Elsevier

2016

Discovery of new selective cytotoxic agents against Bcl-2 expressing cancer cells using ligand-based modeling

Nour H. Aboalhaija, Malek A. Zihlif, Mutasem O. Taha

Chemico-Biological Interactions

250, 12-26

Elsevier

2016

Innovative computer-aided methods for the discovery of new kinase ligands

Areej Abuhammad, Mutasem Taha

Future Medicinal Chemistry

Vol. 8, No. 5, Pages 509-526

Future Science

2016

Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling

Mohammad A. Khanfar, Saja Al-Qtaishat, Maha Habash, Mutasem O. Taha

Chemico-Biological Interactions

254, 93-101

Elsevier

2016

Cytotoxic activity of the novel heterocyclic compound G-11 is primarily mediated through intrinsic apoptotic pathway

Ayman M. Saleh, Mohammad A. Aziz, Ibrahim M. Abdou, Mutasem O. Taha, Mahmoud A. Al-Qudah, Mohammed M. Abadleh, Ahmad Aljada, Syed A. Rizvi.

Apoptosis

Volume 21, Issue 7, pp 873-886

Springer

2016

Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies

Ma’mon M. Hatmal Shadi Jaber Mutasem O. Taha

Journal of Computer-Aided Molecular Design

30, 1149-1163

Springer

2016

Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation

Shada J Alabed Mohammad Khanfar Mutasem O Taha

Future Medicinal Chemistry

Vol. 8, No. 15 , Pages 1841-1869

Future Science Group

2016

Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening

Mahmoud A. Al-Sha'er, Inas S. Almazari, Mutasem O. Taha

Journal of Molecular Recognition

Wiley

2016

Rosmarinic acid reverses the effects of metronidazole-induced infertility in male albino rats

Zina M. Al-Alami, Ziad A. Shraideh Mutasem O. Taha

Reproduction, Fertility and Development

CSIRO publishing

2016

Oleuropein potently inhibits mammalian target of rapamycin: possible involvement of tandem anomeric hyperconjugation– Michael reaction

Mutasem O. Taha • Mohammad A. Khanfar

MEDICINAL CHEMISTRY RESEARCH

24, 616-624

Springer

2015

Ligand-based modeling followed by in vitro bioassay yielded new potent glucokinase activators

Mutasem O. Taha, Maha Habash, Ma’mon M. Hatmal, Ahmed H. Abdelazeem, Amjad Qandil

Journal of Molecular Graphics and Modelling

56: 91–102

Elsevier

2015

Haloperidol inhibits Memapsin 2: Innovation by docking simulation and in vitro assay

Afaf Hasan Al-Nadaf, Mutasem Omar Taha, Hammad Khalifeh Aldal’in

Pakistan Journal of Pharmaceutical Sciences

28: 139-146

University of Karachi

2015

Antiproliferative activity of the isoindigo 5′-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase

Ayman M. Saleh, Mustafa M. El-Abadelah, Mohammad Azhar Aziz, Mutasem O. Taha, Amre Nasr, Syed A.A. Rizvi

Cancer Letters

Vol. 361, p 251–261

Elsevier

2015

Beta-Caryophyllene as putative male contraceptive: enhances spermatogenesis but not spermiogenesis in albino rats

Zina M. Al-Alami Ziad A. Shraideh Mutasem O. Taha

Medicinal Chemistry Research

Volume 24, issue 11, pages 3876–3884

Springer

2015

Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery

Nour Jamal Jaradat Mohammad A. Khanfar Maha Habash Mutasem Omar Taha

Journal of Computer-Aided Molecular Design

Volume 29 Number 6, Pages 561-581

Springer

2015

Synthesis and evaluation of novel diphenylthiazole derivatives as potential anti-inflammatory agents

Ahmed H. Abdelazeem Maha Habash Ibrahim A. Maghrabi Mutasem O. Taha

Medicinal Chemistry Research

Volume 24, Issue 10, pp 3681-3695

Springer

2015

Design, synthesis and structure–activity relationship of new HSL inhibitors guided by pharmacophore models

Jumana D. Al-Shawabkeh

Afaf H. Al-Nadaf

Lina A. Dahabiyeh

Mutasem O. Taha*

Medicinal Chemistry Research

23:127–145

Springer

2014

Preparation and in vitro characterization of glibenclamide-loaded alginate hexyl-amide beads: a novel drug delivery system to improve the dissolution rate

Ahmed Khames, Ahmed H. Abdelazeem, Maha Habash, Mutasem O. Taha

Pharmaceutical Development and Technology

19: 881–890

Informa Healthcare

2014

Synthesis and characterization of new derivatives of alginic acid and evaluation of their iron(III)-crosslinked beads as potential controlled release matrices

Samer R. Abulateefeh, Mohammad A. Khanfar, Ramia Z. Al Bakain, and Mutasem O. Taha*

Pharmaceutical Development and Technology

19: 856–867

Informa HealthCare

2014

Discovery of novel urokinase plasminogen activator (uPA) 5 inhibitors using ligand-based modeling and virtual screening 6 followed by in vitro analysis

Mahmoud A. Al-Sha’er Mohammad A. Khanfar Mutasem O. Taha*

Journal of Molecular Modelling

20:2080-2095

Springer

2014

Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis

MO Taha, MA Al-Sha'er, MA Khanfar, AH Al-Nadaf

European journal of medicinal chemistry

84: 454-465

Elsevier

2014

The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators

Mutasem O. Taha • Maha Habash • Mohammad A. Khanfar

Journal of Computer-Aided Molecular Design

28: 509–54

Springer

2014

Enhanced drug encapsulation and extended release profiles of calcium-alginate nanoparticles by using tannic acid as a bridging cross-linking agent

SR Abulateefeh, MO Taha

Journal of microencapsulation

In Press

informa healthcare

2014

Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3

TMK Motawi, Y Bustanji, S EL-Maraghy, MO Taha, MAS Al-Ghussein

Journal of enzyme inhibition and medicinal chemistry

29 , 153-161

informa healthcare

2014

Synthesis and Antitumor Activities of Some New N1-(Flavon-6-yl)amidrazone Derivatives

AY Habashneh, MM El-Abadelah, MA Zihlif, A Imraish, MO Taha

Archiv der Pharmazie

347 , 415–422

WILEY-VCH Verlag

2014

Preparation of novel ionotropically crosslinked beads based on alginate-terephthalic acid composites as potential controlled release matrices

R Al-Otoum, SR Abulateefeh, MO Taha

Pharmazie

69 , 10-18

Govi Verlag

2014

Elaborate ligand-based modeling reveals new human neutrophil elastase inhibitors

Maha Habash • Ahmed H. Abdelazeem • Mutasem O. Taha

Medicinal Chemistry Research

23:3876–3896

Springer

2014

Tryptophan and thiosemicarbazide derivatives: design, synthesis, and biological evaluation as potential b-D-galactosidase and b-D-glucosidase inhibitors

Reema Abu Khalaf • Ahmed Mutanabbi Abdula • Mohammad S. Mubarak • Mutasem O. Taha

Medicinal Chemistry Research

In Press

Springer

2014

Ritodrine inhibits neuronal nitric oxide synthase, a potential link between tocolysis and autism

Ghadeer A. R. Y. Suaifan • Mayadah B. Shehadeh • Hebah A. N. Al-Ijel • Khuloud T. Al-Jamal • Mutasem O. Taha

Medicinal Chemistry Research

23:5102–5109

Springer

2014

Famotidine inhibits glycogen synthase kinase-3β: An investigation by docking simulation and experimental validation.

Mohammad Mohammad, Ihab M. Al-Masri, Ala Issa, Mohamed A.S. Al-Ghussein, Mohammad Fararjeh, Hatim Alkhatib, Mutasem O. Taha, Yasser Bustanji

Journal of Enzyme Inhibition and Medicinal Chemistry

28, 690-694

Informa Healthcare

2013

Ligand-Based Pharmacophore Exploration and QSAR Analysis of Transition State Analogues followed by In Silico Screening Guide the Discovery of New Sub-Micromolar <beta>-Secreatase Inhibitors

Afaf Al-Nadaf and Mutasem O. Taha*

Medicinal Chemistry Research

22, 1979–1997

Springer

2013

β-Caryophyllene Causes Regression of Endometrial Implants in a Rat Model of Endometriosis without Affecting Fertility

Manal A. Abbas, Mutasem O. Taha, Malek A. Zihlif, Ahmad M. Disi.

European Journal of Pharmacology

702, 12–19

Elsevier

2013

Pharmacophore Modeling, Homology Modeling, and in silico Screening Reveal Mammalian Target of Rapamycin Inhibitory Activities for Sotalol, Glyburide, Metipranolol, Sulfamethizole, Glipizide, and Pioglitazone.

Mohammad A. Khanfar, Majed M. AbuKhader, Saja Alqtaishat, Mutasem O. Taha*

Journal of Molecular Graphics and Modelling

42, 39–49

Elsevier‏

2013

Synthesis of A Novel Chitosan-Based Polymer Employing Ugi Reaction And Application As A Matrix For Controlled Drug Delivery

Ardakani A, Al-Zoubi N, Sakhnini N, Taha MO*

Jordan Journal of Pharmaceutical Sciences

6, 2, 233-241

The Jordanian Ministry of Higher Education

2013

Elaborate Ligand-Based Modeling Reveal New Migration Inhibitory Factor Inhibitors

Mahmoud A.Al-Sha'er, Sonya VanPatten, Yousef Al-Abed, Mutasem O. Taha*

Journal of Molecular Graphics and Modelling (Impact Factor = 2.184)

42, 104–114

Elsiever

2013

Sunitinib as an Anti-Endometriotic Agent

Manal A. Abbas,

Ahmad M. Disi,

Mutasem O. Taha

European Journal of Pharmaceutical Sciences

49, 732-736

Elsevier

2013

Naproxen and Cromolyn as New Glycogen Synthase Kinase 3β Inhibitors Investigated by Docking Simulation and subsequent In vitro/ In vivo Biochemical Evaluation Helps for Diabetes and Obesity

Tarek M. K. Motawi,

Yasser Bustanji,

Shohda EL-Maraghy,

Mutasem O. Taha,

Mohamed A. S. Al Ghussein

Journal of Biochemical and Molecular Toxicology.

27, 425-436

Wiley

2013

Regression of endometrial Implants treated with vitamin D3 in a rat model of endometriosis

Manal A. Abbas,

Mutasem O. Taha,

Ahmad M. Disi,

Maha Shomaf,

European Journal of Pharmacology

715, 72-75

Elsevier

2013

Elaborate Ligand-Based Modeling Coupled with Multiple Linear Regression and k Nearest Neighbor QSAR Analyses Unveiled New Nanomolar mTOR Inhibitors

Mohammad A. Khanfar Mutasem O. Taha

Journal of Chemical Information and Modeling

53, 2587−2612

American Chemical Society

2013

New leads for DPP IV inhibition: structure-based pharmacophore mapping and virtual screening study

Ihab M. Almasri strong>Mutasem O. Taha Mohammad K. Mohammad

Archives of Pharmacal Research

36:1326–1337

Springer

2013

Elaborate ligand-based modeling coupled with QSAR analysis and in silico screening reveal new potent acetylcholinesterase inhibitors

Sawsan Abuhamdah Maha Habash Mutasem O. Taha*

Journal of Computer-Aided Molecular Design

27:1075–1092

Springer

2013

Design, Synthesis and Biological Evaluation of N4-Sulfonamido- Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors

Reema Abu Khalaf, Ghassan Abu Sheikh, Mahmoud Al-Sha'er, Mutasem Taha

The Open Medicinal Chemistry Journal

7, 39-48

Bentham Open

2013

Ethosuximide and Phenobarbital Promote Wound Healing via Enhancing Collagenization

Dema M. Ajwee, Ahmad M. Disi, Eyad A. Qunaibi, Mutasem O. Taha*

Chemical Biology & Drug Design (Impact Factor for 2010 = 2.473)

79(1), 137-142.

Wiley-Blackwell

2012

Rational Exploration of New Pyridinium-Based Hsp90alpha inhibitors Tailored To Thiamine Structure

Mahmoud A.Al-Sha'er, Mutasem O. Taha*

Medicinal Chemistry Research (Impact Factor= 1.037)

21, 487-510

Springer

2012

Elaborate Ligand-Based Modeling and Subsequent Synthetic Exploration Unveil New Nanomolar Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitory Leads

Rand Shahin and Mutasem O. Taha*

Bioorganic & Medicinal Chemistry (Impact Factor for 2010 = 2.978)

20, 377–400

Elsevier

2012

Elaborate Ligand-Based Modeling Reveal New Submicromolar Rho Kinase Inhibitors

Rand Shahin, Saja AlQtaishat, Mutasem O. Taha*

Journal of Computer-Aided Molecular Design (Impac Factor = 3.374)

26, 249-266

Springer

2012

Design, synthesis, and biological evaluation of sulfonic acid ester and benzenesulfonamide derivatives as potential CETP inhibitors

Reema Abu Khalaf, Ghassan Abu Sheikha, Mahmoud Al-Sha’er, Ghadeer Albadawi, Mutasem Taha

Medicinal Chemistry Research (Impact Factor for 2010 = 1.058)

21:3669–3680

Springer

2012

Effect of particle morphology and pore size on the release kinetics of ephedrine from mesoporous MCM-41 materials

Dua’a M. Marzouqa, Mohammad B. Zughul, Mutasem O. Taha, Hamdallah A. Hodali

Journal of Porous Materials (Impact Factor for 2010 = 0.984)

19, 825-833

Springer

2012

Formulation and Characterization of IPM/Water/Nonionic-Ionic Surfactant Microemulsions

Enam Khalil, Shorouq T. Al-Sotari and Mutasem O. Taha

J. Chem. Chem. Eng.

6, 187-198

DAVID PUBLISHING

2012

Extensive Ligand-Based Modeling And In Silico Screening Reveal Nanomolar Inducible Nitric Oxide Synthase (iNOS) Inhibitors

Ghadeer A.R.Y. Suaifan, Mayyada Shehadehh, Hebah Al-Ijel, Mutasem Taha*

Journal of Molecular graphics and Modelling (Impact Factor 2.038)

37, 1-26

Elsevier

2012

Pharmacophore and QSAR Modeling of Endotholial Nitric Oxide Synthase Inhibitors and Subsequent Validation and In Silico Search for New Hits

Ghadeer A. R. Y. Suaifan, Heba A. N. Al-Ejal, Mutasem O. Taha*

Jordan Journal Of Pharmaceutical Sciences

5, 220-244

Jordan Ministry of Higher Education

2012

Synthesis and biological activity assays of some new N1-(flavon-7-yl) amidrazone derivatives and related congeners

Marwa N. Abu-Aisheh, Mohammad S. Mustafa, Mustafa M. El-Abadelah, Randa G. Naffa, Said I. Ismail, Malek A. Zihlif, Mutasem O. Taha, Mohammad S. Mubarak*

European Journal of Medicinal Chemistry (Impact Factor for 2010 = 3.193)

54, 65-74

Elsevier

2012

Application of Docking-Based Comparative Intermolecular Contacts Analysis for Validating Hsp90α Docking Studies and Subsequent In Silico screening for Inhibitors

Mahmoud A.Al-Sha'er, Mutasem O. Taha*

Journal of Molecular Modelling

18, 11, pp 4843-4863

Springer

2012

Discovery of New β-D-Glucosidase Inhibitors via Pharmacophore Modeling and QSAR Analysis Followed by In Silico Screening

Reema Abu Khalaf, Ahmed Mutanabbi Abdula, Mohammad S. Mubarak, Mutasem O. Taha*

Journal of Molecular Modeling (ISI Impact Factor 2008 = 2.018)

17, 443–464

Springer

2011

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Published Research